Bruins beat Sabres 6-2 for 5th straight win
Brad Marchand had a goal and two assists, Rich Peverley and Chris Kelly had a goal and an assist each, and Zdeno Chara assisted on two goals for Boston (8-7), which has a winning record for the first time this season.
The Bruins, who got goals 16 seconds apart from Seguin and Nathan Horton in the second period, have scored 30 goals during their longest streak since winning seven straight last spring.
Tim Thomas made 21 saves as the Bruins held the Sabres to 23 shots and ended Buffalo's four-game winning streak.
Ryan Miller stopped 19 of 22 shots before being pulled after the second period.
Seguin has 11 goals, matching his total from last season when he was a rookie with the Stanley Cup champion Bruins. He put the Bruins up 2-1 when he and Marchand broke free for a 2-on-1 break with 6:31 left in the second. Marchand grabbed a turnover at center ice, then slipped a crossing pass to set up an easy chip in for Seguin's 10th goal.
Fans didn't even have a chance to sit down before Horton skated down the left side and fired a wrist shot past Miller to put Boston ahead 3-1 with 6:15 remaining.
It was the ninth time this season the Bruins have scored two goals in less than a minute.
Miller was replaced by Jhonas Enroth for the third period, the second time in three games Miller has been pulled.
Buffalo's backup didn't stand a chance when Peverley slipped a pass across the crease to Kelly for an easy tap-in with 14:32 left, and again on Seguin's second of the game.
Patrice Bergeron broke to the left and dropped a backhand pass to the slot, where Seguin fired a one-timer past Enroth to make it 5-1 with 12:49 remaining.
Marchand added a goal on a backhander with 10:08 to play.
Marc-Andre Grangnani scored his first goal of the season for Buffalo late in the third period.
Buffalo took a 1-0 on a misplay by Thomas, who got handcuffed on a shot by Thomas Vanek. Thomas knocked the puck back behind the net and Vanek banked the rebound off Thomas' pads and into the net with 14:22 left.
Boston tied it when Peverley scored with 12:20 left in the second.
The game was chippy throughout, especially after Boston's Milan Lucic nearly had a breakaway until Miller skated out and played the puck, then got leveled by Lucic. Miller's mask flew off and he took a wild swipe from his seat at Lucic with his goalie stick just before two Sabres pounced on Lucic.
Lucic was given a minor penalty for charging.
NOTES: Jason Pominville got an assist on Buffalo's first goal, his 14th in 16 games. ... The Bruins improved to 7-0 when leading after two periods. ... Seguin has a goal in four straight games and 14 points in nine games. ... Marchand has at least a point in five consecutive games. ... Lucic's streak of five straight games with a goal ended. ... Buffalo's Nathan Gerbe played in his 100th NHL game.