1. Dan Orlovsky vs. Patriots defensive backs
The notion that Peyton Manning deserves a nod of MVP consideration because the Colts have collapsed without him is a ridiculous one, but his injury and season-long absence has confirmed that he is the most irreplaceable player to his particular team in the entire NFL. Backup Curtis Painter flopped in nine starts (66.6 quarterback rating), and he was Benched in favor of former UConn quarterback Orlovsky this week. The last significant action he's seen in the NFL came in seven starts for the 2008 Detroit Lions, who went 0-16.