Hoyer, 35, has been with the Sox since 2002. He and Ben Cherington directed baseball operations during Epsteinís 10-week hiatus following the 2005 season. Hoyer has since interviewed with the Pirates and Nationals during their GM searches.
The Padres are seeking a replacement for Kevin Towers, who was fired this month. Towers is said to have a standing offer to join Epsteinís staff.