In the latest skirmish in an intensifying battle over the price of an AIDS drug, patient advocates appealed to federal regulators this week to force a major drug company to roll back a substantial price increase.
The National Institutes of Health held a hearing Tuesday in Bethesda, Md., on whether it should compel
The hearing was held amid an ongoing protest of the price increase by several hundred doctors, including physicians at the Fenway Community Health Center in Boston.
The protest has resulted in physicians boycotting Abbott's drugs, shunning its sales representatives, and severing research relationships.
Abbott executives responded that they are attempting to earn a fair return on a medicine originally designed to be taken many times daily but now typically used only once or twice a day to enhance the effectiveness of other companies' drugs.
As part of their petition, the patient advocates have asked the NIH to allow other companies to make and sell Norvir in an effort to reduce its cost.
In rare cases, the 1980 Bayh-Dole Act lets the government step in and grant licenses for other companies to make the products it helped finance. If the government should do that with Norvir, it would be the first time that had been done with a privately patented drug.
James Love -- president of Essential Innovations Inc., a nonprofit group in Washington, D.C. -- charged that the cost increase is an abuse of pricing practices. Robert Huff, of Gay Men's Health Crisis in New York, contended that because Norvir is used as a booster with many other AIDS drugs, Abbott raised the price in an effort to increase the cost of using other firms' drugs.
The price increase ''will inhibit innovation, restrict research, limit medical options, and hurt people with HIV," Huff said.
Dr. Jeffrey M. Leiden, president of the Pharmaceutical Products Group at Abbott, told the meeting at the NIH that despite the 400 percent increase in December, from $1.71 per day to $8.57 per day, Norvir remains one of the least expensive AIDS drugs.
The company needs to earn back the approximately $300 million it spent developing Norvir, he said. NIH provided a basic research grant for the drug of about $3.5 million.
Shares of Illinois-based Abbott rose $1.07 to $40.62 on the New York Stock Exchange Tuesday.
Ted Poehler of Johns Hopkins University, representing the American Association of Universities, said that releasing Norvir to other manufacturers would introduce an element of uncertainty among researchers that could discourage development of new drugs.
Former Indiana Senator Birch Bayh, who coauthored the law that would permit the government action, said his intent was not to have the government set prices. His aim, Bayh said, had been to prevent a company from licensing a product and then holding off development of it to protect another product already on sale.
Mark L. Rohrbaugh, director of the NIH Office of Technology Transfer, and his deputy, Bonny Harbinger, will report on the meeting to NIH director Elias Zerhouni, who will make the final decision.
Stephen Smith of the Globe staff contributed to this report.