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Parexel test subjects have multiple organ damage

THE REGION

All six of the men hospitalized in London after receiving an experimental drug in a Parexel International Corp. trial suffered ''multiple organ failure," according to a Northwick Park Hospital spokesman. Two of the participants are in critical condition, British health authorities said. Four others who are in serious condition are showing signs of improvement, according to Ganesh Suntharalingam, the hospital's clinical director of intensive care. Waltham-based Parexel was testing the safety of a compound called TGN 1412, developed by Germany's closely held TeGenero AG to treat conditions including rheumatoid arthritis and leukemia. Parexel shares fell $1.62, or 6.3 percent, to $24.17. (Bloomberg)

Logan to add round trips to Pittsburgh, Buffalo
JetBlue Airways Corp. said it will begin offering service from Boston to Buffalo and Pittsburgh in June. That will bring to 18 the number of destinations served nonstop by JetBlue, once planned service to Richmond, and Phoenix begins in the next two months. JetBlue plans to charge round-trip fares of $138 to $268 to Pittsburgh and $118 to $268 to Buffalo, with $10 added for tickets bought by phone, spokeswoman Jenny Dervin said. JetBlue will offer three daily flights to Buffalo and two to Pittsburgh from Boston, Dervin said. US Airways now offers the only nonstops from Logan to those cities. (Peter J. Howe)

Massport awards security contract for Logan access
The Massachusetts Port Authority, which runs Logan International Airport, has awarded Tour Andover Controls, part of multinational technology conglomerate Schneider Electric, a $5.1 million, 14-month contract to maintain security networks at Logan. Tour Andover will be responsible for maintaining 650 closed-circuit TV cameras and more than 300 handprint and eye-scanning devices used in 800 locations to restrict access to sensitive areas. Tour Andover, which has a local office in North Andover, will be eligible for two one-year contract extensions in 2007 and 2008, Massport secretary-treasurer Leslie A. Kirwan said. (Peter J. Howe)

Group seeks more full-time jobs at packaging center
A group of churches and labor organizations said Gillette Co. has made improvements in job conditions at its packaging center in Devens but the coalition, known as the Merrimack Valley Project, is calling on Gillette and its parent Procter & Gamble Co., to increase the number of permanent jobs there. According to the group, about two-thirds of the 1,000 workers are temporary. Gillette spokesman Eric Kraus said the company uses a business model in which the contractors who operate its Devens facility employ temporary workers to meet Gillette's highly variable needs for seasonal and promotional packaging. But Gillette this week agreed to conduct a study of the operation to explore opportunities to create more job stability, the coalition said. (Jenn Abelson)

Mangosoft shares plunge 70% after lawsuit ruling
Mangosoft Inc. shares plunged 70.1 percent after it lost a patent suit in which it sought as much as $500 million from Oracle Corp. over database software. Nashua-based Mangosoft sued in 2002, claiming that Oracle's 9i and 10g database software infringed a Mangosoft patent. In a ruling Tuesday, US District Judge Steven J. McAuliffe in Concord, N.H., sided with Oracle's argument that it didn't infringe the patent because it didn't use the same process. Shares fell $4.12 to $1.76. (Bloomberg)

Relational Investors hires ex-SEC chief for advice
Relational Investors LLC, the activist investment firm fighting to win seats on the board of Sovereign Bancorp, has hired former Securities and Exchange Commission chairman Richard Breeden as an adviser, Relational principal Ralph Whitworth said. Relational owns about 8 percent of Sovereign's shares. (Reuters)

Fisher Scientific to buy 1 company, part of another
Fisher Scientific International Inc. will acquire closely held Athena Diagnostics Inc. and 9 percent of Nanogen Inc. to expand gene testing and other diagnostic services. Hampton, N.H.-based Fisher, a provider of laboratory supplies and services, said it will pay $283 million cash for Worcester-based Athena and $15 million cash for the Nanogen stake. Athena sells diagnostics for Alzheimer's disease, multiple sclerosis, and other neurological and muscular disorders. Nanogen sells equipment and supplies for molecular tests. (Bloomberg)

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