Daryl Hannah was "blacklisted" from Hollywood because she suffered from Asperger's Syndrome.
The 'Splash' actress was diagnosed with the illness - which limits social interaction - early in her career and admits she almost ruined her professional life because she was so nervous of doing promotion as it involved talking to lots of people.
She said: "I never went on talk shows, never went to premieres. Going to the Academy Awards was so painful for me. I'd almost faint just walking down the red carpet. I was so socially awkward and uncomfortable that I eventually got blacklisted.
"Studio executives would call me but I'd be too shy to call them back. So after a while a couple of studios literally told my manager that I was blacklisted."
Although her career was almost over before it had begun, Daryl - who turns 50 this year - claims she would never put her work before her personal life.
She said: "If something in my personal life comes up that moves me - whether it's because my father was ill, or because I want to spend time with my boyfriend - I will prioritize that over taking a movie part. That's the way I've been throughout my life."